Dr. J.W. (Jan Willem) de Gee
Faculty of Science
Swammerdam Institute for Life Sciences
Visiting address
- Science Park 904
- Room number: C4.102
Postal address
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Postbus 94246
1090 GE Amsterdam
Contact details
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Research statement
My main interest lies in how neuromodulatory signals shape the neural computations underlying consciousness and decision-making in health and disease. I believe that the most exciting answers can be gained from research that actively integrates behavior, computation, and imaging of brain-wide networks with measurements and manipulations of neural circuits and individual neurons. To that end, my lab leverages a unique cross-species approach: ensemble (e.g. neuropixel) recordings, 2-photon imaging and optogenetics in mice, M/EEG and fMRI in humans, and pupillometry and computational modeling of behavior in both species.
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Collaborations
On neuromodulatory shaping of perception and decision-making in mice:
- Prof. Cyriel Pennartz: ensemble recordings and optogenetics
- Dr. Umberto Olcese: ensemble recordings and optogenetics
- Dr. Matthew McGinley: pupillometry and genetically encoded sensorsOn neuromodulatory shaping of perception and decision-making in humans:
- Prof. Tobias Donner: MEG
- Dr. Simon van Gaal: EEG
- Dr. Jorge Mejias: computational modelingMethods:
- Dr. Mototaka Suzuki: genetically encoded sensors
- Dr. Conrado Bosman: time-frequency (functional connectivity) analyses
- Dr. Tomas Knapen: layer-specific fMRI (“line scanning”) -
Publications
2024
Beerendonk, L., Mejías, J. F., Nuiten, S. A., de Gee, J. W., Fahrenfort, J. J., & van Gaal, S. (2024). A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousal. Proceedings of the National Academy of Sciences of the United States of America, 121(5), Article e2312898121. https://doi.org/10.1073/pnas.2312898121 [details]- Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2024). Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight. eNeuro, 11(7), Article ENEURO.0019-24.2024. https://doi.org/10.1523/ENEURO.0019-24.2024 [details]
2023
- Mazancieux, A., Mauconduit, F., Amadon, A., de Gee, J. W., Donner, T. H., & Meyniel, F. (2023). Brainstem fMRI signaling of surprise across different types of deviant stimuli. Cell Reports, 42(11), Article 113405. https://doi.org/10.1016/j.celrep.2023.113405 [details]
- Nuiten, S. A., De Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2023). Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision making. eLife, 12. Advance online publication. https://doi.org/10.7554/eLife.87022.3
2022
- Colizoli, O., de Gee, J. W., van der Zwaag, W., & Donner, T. H. (2022). Functional magnetic resonance imaging responses during perceptual decision-making at 3 and 7 T in human cortex, striatum, and brainstem. Human Brain Mapping, 43(4), 1265-1279. Advance online publication. https://doi.org/10.1002/hbm.25719 [details]
2021
- Mridha, Z., de Gee, J. W., Shi, Y., Alkashgari, R., Williams, J., Suminski, A., Ward, M. P., Zhang, W., & McGinley, M. J. (2021). Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve. Nature Communications, 12(1), Article 1539. https://doi.org/10.1038/s41467-021-21730-2
- de Gee, J. W., Correa, C. M. C., Weaver, M., Donner, T. H., & van Gaal, S. (2021). Pupil Dilation and the Slow Wave ERP Reflect Surprise about Choice Outcome Resulting from Intrinsic Variability in Decision Confidence. Cerebral Cortex, 31(7), 3565-3578. Advance online publication. https://doi.org/10.1093/cercor/bhab032 [details]
2020
- de Gee, J. W., Tsetsos, K., Schwabe, L., Urai, A. E., McCormick, D., McGinley, M. J., & Donner, T. H. (2020). Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains. eLife, 9, Article e54014. https://doi.org/10.7554/eLife.54014 [details]
2019
- Kloosterman, N. A., de Gee, J. W., Werkle-Bergner, M., Lindenberger, U., Garrett, D. D., & Fahrenfort, J. J. (2019). Humans strategically shift decision bias by flexibly adjusting sensory evidence accumulation. eLife, 8, Article e37321. https://doi.org/10.7554/eLife.37321 [details]
- Urai, A. E., de Gee, J. W., Tsetsos, K., & Donner, T. H. (2019). Choice history biases subsequent evidence accumulation. eLife, 8, Article e46331. https://doi.org/10.7554/eLife.46331 [details]
2018
- Colizoli, O., de Gee, J. W., Urai, A. E., & Donner, T. H. (2018). Task-evoked pupil responses reflect internal belief states. Scientific Reports, 8, Article 13702. https://doi.org/10.1038/s41598-018-31985-3 [details]
2017
- de Gee, J. W., Colizoli, O., Kloosterman, N. A., Knapen, T., Nieuwenhuis, S., & Donner, T. H. (2017). Dynamic modulation of decision biases by brainstem arousal systems. eLife, 6, Article e23232. https://doi.org/10.7554/eLife.23232 [details]
2016
- Knapen, T., de Gee, J. W., Brascamp, J., Nuiten, S., Hoppenbrouwers, S., & Theeuwes, J. (2016). Cognitive and Ocular Factors Jointly Determine Pupil Responses under Equiluminance. PLoS ONE, 11(5), Article e0155574. https://doi.org/10.1371/journal.pone.0155574 [details]
2014
- de Gee, J. W., Knapen, T., & Donner, T. H. (2014). Decision-related pupil dilation reflects upcoming choice and individual bias. Proceedings of the National Academy of Sciences of the United States of America, 111(5), E618-E625. https://doi.org/10.1073/pnas.1317557111 [details]
2024
- Donner, T. H., van Gaal, S., Schwabe, L. & de Gee, J. (2-10-2024). Task-irrelevant stimuli reliably boost phasic pupil-linked arousal but do not affect decision formation. Universität Hamburg. https://doi.org/10.25592/uhhfdm.15976
- de Gee, J. & McGinley, M. (7-6-2024). Data and analysis code from "Strategic stabilization of arousal boosts sustained attention". Zenodo. https://doi.org/10.5281/zenodo.11517468
2019
- Urai, A. E., Tsetsos, K., Donner, T. H. & De Gee, J. (2019). Urai et al. (2019) Choice history biases subsequent evidence accumulation. eLife, in press. Figshare. https://doi.org/10.6084/m9.figshare.7268558
2018
- Kloosterman, N. A., Garrett, D. D., Fahrenfort, J., De Gee, J., Bergner, M. Werkle. & Lindenberger, U. (2018). Data from: Humans strategically shift decision bias by flexibly adjusting sensory evidence accumulation in visual cortex. Figshare. https://doi.org/10.6084/m9.figshare.6142940
2017
- de Gee, J., Knapen, T. & Donner, T. H. (2017). Data set: Decision-related pupil dilation reflects upcoming choice and individual bias.. Figshare. https://doi.org/10.6084/m9.figshare.4806559.v2
- de Gee, J., Colizoli, O., Kloosterman, N., Knapen, T., Nieuwenhuis, S. & Donner, T. H. (2017). Data set: Dynamic modulation of decision biases by brainstem arousal systems. Figshare. https://doi.org/10.6084/m9.figshare.4806562.v1
- de Gee, J., Colizoli, O., Kloosterman, N., Knapen, T., Nieuwenhuis, S. & Donner, T. H. (2017). Data set: Dynamic modulation of decision biases by brainstem arousal systems. Figshare. https://doi.org/10.6084/m9.figshare.4806562
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Ancillary activities
- No ancillary activities
Beerendonk, L., Mejías, J. F., Nuiten, S. A., de Gee, J. W., Fahrenfort, J. J., & van Gaal, S. (2024). A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousal. Proceedings of the National Academy of Sciences of the United States of America, 121(5), Article e2312898121.